There's cleaning and then there's deep cleaning. Deep cleaning is the serious sort of intensive work you do when you are putting a house on the market, preparing for a visit-from your in-laws, or when you have some type of OCD-driven itch that must be scratched.
I'm not the greatest housekeeper, but when it's time to do a deep cleaning I am fortunate to have a good partner in Ron. We put on our work clothes (which should be disposable if things really get ugly), roll up our sleeves, crank up some country music, and get to it.
It's hard work to scoot along the floor on your butt to wash the baseboards, crawl across the bathroom floor with a toothbrush and bleach water to scrub the grout, unload cabinets to wipe them out, climb up and down ladders reaching with a sponge to clean walls, and push a mop along the floors. We're doing this now to freshen Mom's house while she is in the hospital. It's important for an open heart surgery patient to be in as germ-free an environment as possible. We won't get them all, but we are definitely running some of them out of town. Dust balls live in fear of us.
The reward is the obvious improvement you can see after the work is done. Everything is brighter and smells fresh. And Mom will be more comfortable in her home. It's all worth the effort.